The DDC has a strong interest in the pharmacology of cognitive
processes involved in e.g. addiction behavior and ADHD. To that end,
the group of Schoffelmeer studies e.g. the effects of peripheral and
intracerebral administration of compounds in rats and mice using a
variety of behavioral paradigms to study psychomotor activity (video
tracking), reinforcement learning and motivation (i.v. and oral drug
self-administration, compulsive drug-seeking), attention and impulsivity
(5-choice serial reaction time task, delayed reward task) and anxiety
(elevated plus-maze, Vogel conflict, forced swimming, social defeat).
Jacobs EH, Smit AB, de Vries TJ and ANM Schoffelmeer (2003) Neuroadaptive
effects of active versus passive drug administration in addiction
research. Trends Pharmacol Sci 24: 566-573.
Jacobs EH, S Spijker, CW Verhoog, K Kamprath, TJ De Vries, AB Smit and
ANM Schoffelmeer (2002) Active heroin administration induces specific
genomic responses in the nucleus accumbens shell. FASEB J 16: 1961-1963.
Schoffelmeer ANM, TJ De Vries, G Wardeh, M Van de Ven and LJMJ
Vanderschuren (2002) Psychostimulant-induced behavioral sensitization
depends on nicotinic receptor activation. J Neurosci 22: 3269-3276.
De Vries TJ and TS Shippenberg (2002) Neural systems underlying opiate
addiction. J Neurosci 22: 3321-3325.
Homberg JR, M van den Akker, HS Raaso, G Wardeh, R Binnekade, ANM
Schoffelmeer and TJ De Vries (2002) Enhanced motivation to self-administer
cocaine is predicted by self-grooming behaviour and relates to dopamine
release in the medial prefrontal cortex and amygdala. Eur J Neurosci
De Vries TJ, Y Shaham, JE Homberg, H Crombag, K Schuurman, J Dieben,
LJMJ Vanderschuren and ANM Schoffelmeer (2001) A cannabinoid mechanism
in relapse to cocaine-seeking. Nature Medicine 7: 1151-1154.
Vanderschuren LJMJ, ED Schmidt, TJ De Vries, CAP van Moorsel, FJH
Tilders and ANM Schoffelmeer (1999). A single exposure to amphetamine
is sufficient to induce long-term behavioral, neuroendocrine and
neurochemical sensitization in rats. J Neurosci 19: 9579-9586.